Ontology highlight
ABSTRACT:
SUBMITTER: Bergstrom DE
PROVIDER: S-EPMC2700755 | biostudies-literature | 2000 Nov-Dec
REPOSITORIES: biostudies-literature
Bergstrom D E DE Young M M Albrecht K H KH Eicher E M EM
Genesis (New York, N.Y. : 2000) 20001101 3-4
Sox genes encode proteins related to each other, and to the sex determining gene Sry, by the presence of a DNA binding motif known as the HMG domain. Although HMG domains can bind to related DNA sequences, Sox gene products may achieve target gene specificity by binding to preferred target sequences or by interacting with specific partner proteins. To assess their functional similarities, we replaced the HMG box of Sry with the HMG box of Sox3 or Sox9 and tested whether these constructs caused s ...[more]