Ontology highlight
ABSTRACT:
SUBMITTER: Rashidian J
PROVIDER: S-EPMC1236525 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Rashidian Juliet J Iyirhiaro Grace G Aleyasin Hossein H Rios Mario M Vincent Inez I Callaghan Steven S Bland Ross J RJ Slack Ruth S RS During Matthew J MJ Park David S DS
Proceedings of the National Academy of Sciences of the United States of America 20050915 39
The mechanisms involving neuronal death after ischemic/hypoxic insult are complex, involving both rapid (excitotoxic) and delayed (apoptotic-like) processes. Recent evidence suggests that cell cycle regulators such as cyclin-dependent kinases are abnormally activated in neuropathological conditions, including stroke. However, the function of this activation is unclear. Here, we provide evidence that inhibition of the cell cycle regulator, Cdk4, and its activator, cyclinD1, plays critical roles i ...[more]