Ontology highlight
ABSTRACT:
SUBMITTER: Neher JJ
PROVIDER: S-EPMC3808587 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Neher Jonas J JJ Emmrich Julius V JV Fricker Michael M Mander Palwinder K PK Théry Clotilde C Brown Guy C GC
Proceedings of the National Academy of Sciences of the United States of America 20131007 43
Delayed neuronal loss and brain atrophy after cerebral ischemia contribute to stroke and dementia pathology, but the mechanisms are poorly understood. Phagocytic removal of neurons is generally assumed to be beneficial and to occur only after neuronal death. However, we report herein that inhibition of phagocytosis can prevent delayed loss and death of functional neurons after transient brain ischemia. Two phagocytic proteins, Mer receptor tyrosine kinase (MerTK) and Milk fat globule EGF-like fa ...[more]