Initiation of the power stroke in muscle: insights from the phosphate analog AlF4.
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ABSTRACT:
SUBMITTER: Kraft T
PROVIDER: S-EPMC1236544 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Publications
Initiation of the power stroke in muscle: insights from the phosphate analog AlF4.
Kraft Theresia T Mählmann Enke E Mattei Thomas T Brenner Bernhard B
Proceedings of the National Academy of Sciences of the United States of America 20050920 39
Motile forces in muscle are generated by the so-called "power stroke," a series of structural changes in the actomyosin cross-bridge driven by hydrolysis of ATP. The initiation of this power stroke is closely related to phosphate release after ATP cleavage and to the change of the myosin head from weak, nonstereospecific actin attachment to strong, stereospecific binding. The exact sequence of events, however, is highly controversial but crucial for the mechanism of how ATP hydrolysis drives str ...[more]
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