Ontology highlight
ABSTRACT:
SUBMITTER: Nobukuni T
PROVIDER: S-EPMC1242323 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Nobukuni Takahiro T Joaquin Manel M Roccio Marta M Dann Stephen G SG Kim So Young SY Gulati Pawan P Byfield Maya P MP Backer Jonathan M JM Natt Francois F Bos Johannes L JL Zwartkruis Fried J T FJ Thomas George G
Proceedings of the National Academy of Sciences of the United States of America 20050921 40
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathway to control the growth and development of the organism. Insulin regulates mTOR function through a recently described canonical signaling pathway, which is initiated by the activation of class 1 PI3K. However, how the amino acid input is integrated w ...[more]