Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: BIOMD0000000640
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Myoblast
SUBMITTER: Horvatovich Péter
LAB HEAD: Kathrin Thedieck
PROVIDER: PXD003073 | Pride | 2016-12-12
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 150 |
Dalle Pezze Piero P Ruf Stefanie S Sonntag Annika G AG Langelaar-Makkinje Miriam M Hall Philip P Heberle Alexander M AM Razquin Navas Patricia P van Eunen Karen K Tölle Regine C RC Schwarz Jennifer J JJ Wiese Heike H Warscheid Bettina B Deitersen Jana J Stork Björn B Fäßler Erik E Schäuble Sascha S Hahn Udo U Horvatovich Peter P Shanley Daryl P DP Thedieck Kathrin K
Nature communications 20161121
Amino acids (aa) are not only building blocks for proteins, but also signalling molecules, with the mammalian target of rapamycin complex 1 (mTORC1) acting as a key mediator. However, little is known about whether aa, independently of mTORC1, activate other kinases of the mTOR signalling network. To delineate aa-stimulated mTOR network dynamics, we here combine a computational-experimental approach with text mining-enhanced quantitative proteomics. We report that AMP-activated protein kinase (AM ...[more]