Inosine induces axonal rewiring and improves behavioral outcome after stroke.
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ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC124418 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Publications
Inosine induces axonal rewiring and improves behavioral outcome after stroke.
Chen Peng P Goldberg David E DE Kolb Bryan B Lanser Marc M Benowitz Larry I LI
Proceedings of the National Academy of Sciences of the United States of America 20020601 13
Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo. We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated ...[more]
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