Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome.
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ABSTRACT:
SUBMITTER: Yoon JS
PROVIDER: S-EPMC3031782 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
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Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome.
Yoon Jeong Seon JS Lee Jong-Hwan JH Son Tae Gen TG Mughal Mohamed R MR Greig Nigel H NH Mattson Mark P MP
Neurobiology of disease 20101124 3
Pregabalin, a Ca(2+) channel α(2)δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke. Pregabalin administration (5-10mg/kg, i.p.) 30-90 min after transient middle cerebral artery occlusion/reperfusion reduced infarct volume, neuronal death in the ischemic penumbra and neurological deficits at 24h post-stroke. Pregabalin significantly decreased the amount of Ca(2+)/calpain-mediated α-spectr ...[more]
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