Ontology highlight
ABSTRACT:
SUBMITTER: Williams RW
PROVIDER: S-EPMC124499 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Williams Robert W RW Rubin Gerald M GM
Proceedings of the National Academy of Sciences of the United States of America 20020501 10
Double-stranded RNA (dsRNA) triggers homology-dependent posttranscriptional gene interference (RNAi) in a diverse range of eukaryotic organisms, in a process mechanistically related to viral and transgene-mediated cosuppression. RNAi is characterized by the conversion of long dsRNA into approximately 21-25-nt small interfering RNAs (siRNA) that guide the degradation of homologous mRNA. Many of the genes required for siRNA production and target mRNA degradation are widely conserved. Notably, memb ...[more]