Ontology highlight
ABSTRACT:
SUBMITTER: Dudley NR
PROVIDER: S-EPMC123624 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Dudley Nathaniel R NR Labbé Jean-Claude JC Goldstein Bob B
Proceedings of the National Academy of Sciences of the United States of America 20020319 7
RNA interference (RNAi) is a phenomenon in which double-stranded RNA (dsRNA) silences endogenous gene expression. By injecting pools of dsRNAs into Caenorhabditis elegans, we identified a dsRNA that acts as a potent suppressor of the RNAi mechanism. We have used coinjection of dsRNAs to identify four additional candidates for genes involved in the RNAi mechanism in C. elegans. Three of the genes are C. elegans mes genes, some of which encode homologs of the Drosophila chromatin-binding Polycomb- ...[more]