Ontology highlight
ABSTRACT:
SUBMITTER: Beggah AT
PROVIDER: S-EPMC124545 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Beggah Ahmed T AT Escoubet Brigitte B Puttini Stefania S Cailmail Stephane S Delage Vanessa V Ouvrard-Pascaud Antoine A Bocchi Brigitte B Peuchmaur Michel M Delcayre Claude C Farman Nicolette N Jaisser Frederic F
Proceedings of the National Academy of Sciences of the United States of America 20020507 10
Cardiac failure is a common feature in the evolution of cardiac disease. Among the determinants of cardiac failure, the renin-angiotensin-aldosterone system has a central role, and antagonism of the mineralocorticoid receptor (MR) has been proposed as a therapeutic strategy. In this study, we questioned the role of the MR, not of aldosterone, on heart function, using an inducible and cardiac-specific transgenic mouse model. We have generated a conditional knock-down model by expressing solely in ...[more]