Ontology highlight
ABSTRACT:
SUBMITTER: Ouvrard-Pascaud A
PROVIDER: S-EPMC3635833 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Ouvrard-Pascaud Antoine A Sainte-Marie Yannis Y Bénitah Jean-Pierre JP Perrier Romain R Soukaseum Christelle C Nguyen Dinh Cat Aurelie A Royer Anne A Le Quang Khai K Charpentier Flavien F Demolombe Sophie S Mechta-Grigoriou Fatima F Beggah Ahmed T AT Maison-Blanche Pierre P Oblin Marie-Edith ME Delcayre Claude C Fishman Glenn I GI Farman Nicolette N Escoubet Brigitte B Jaisser Frederic F
Circulation 20050606 23
<h4>Background</h4>Life-threatening cardiac arrhythmia is a major source of mortality worldwide. Besides rare inherited monogenic diseases such as long-QT or Brugada syndromes, which reflect abnormalities in ion fluxes across cardiac ion channels as a final common pathway, arrhythmias are most frequently acquired and associated with heart disease. The mineralocorticoid hormone aldosterone is an important contributor to morbidity and mortality in heart failure, but its mechanisms of action are in ...[more]