Ontology highlight
ABSTRACT:
SUBMITTER: Nakatani Y
PROVIDER: S-EPMC1247991 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Nakatani Yoshihiro Y Konishi Hiroaki H Vassilev Alex A Kurooka Hisanori H Ishiguro Keiichiro K Sawada Jun-ichi J Ikura Tsuyoshi T Korsmeyer Stanley J SJ Qin Jun J Herlitz Anna M AM
Proceedings of the National Academy of Sciences of the United States of America 20051007 42
In this article, we identify and characterize p600, a unique 600-kDa retinoblastoma protein- and calmodulin-binding protein. In the nucleus, p600 and retinoblastoma protein seem to act as a chromatin scaffold. In the cytoplasm, p600 and clathrin form a meshwork structure, which could contribute to cytoskeletal organization and membrane morphogenesis. Reduced expression of p600 with interference RNA abrogates integrin-mediated ruffled membrane formation and, furthermore, prevents activation of in ...[more]