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Detection of measles virus mRNA from autopsied human tissues.

ABSTRACT: By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals.

SUBMITTER: Katayama Y

PROVIDER: S-EPMC124860 | biostudies-literature | 1998 Jan

REPOSITORIES: biostudies-literature

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Detection of measles virus mRNA from autopsied human tissues.

Katayama Y Y Kohso K K Nishimura A A Tatsuno Y Y Homma M M Hotta H H

Journal of clinical microbiology 19980101 1

By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals. ...[more]

PMID: 9431973

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