Ontology highlight
ABSTRACT:
SUBMITTER: Bamshad MJ
PROVIDER: S-EPMC124967 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Bamshad Michael J MJ Mummidi Srinivas S Gonzalez Enrique E Ahuja Seema S SS Dunn Diane M DM Watkins W Scott WS Wooding Stephen S Stone Anne C AC Jorde Lynn B LB Weiss Robert B RB Ahuja Sunil K SK
Proceedings of the National Academy of Sciences of the United States of America 20020729 16
CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5, suggesting that it may have been a target of natural selection. We characterized CCR5 sequence variation in this region in 400 chromosomes from worldwide populations and compared ...[more]