Ontology highlight
ABSTRACT:
SUBMITTER: Takeda H
PROVIDER: S-EPMC124971 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Takeda Haruko H Takami Marika M Oguni Tomoko T Tsuji Takehito T Yoneda Kazuhiro K Sato Hiroaki H Ihara Naoya N Itoh Tomohito T Kata Srinivas R SR Mishina Yuji Y Womack James E JE Moritomo Yasuo Y Sugimoto Yoshikazu Y Kunieda Tetsuo T
Proceedings of the National Academy of Sciences of the United States of America 20020722 16
Chondrodysplastic dwarfism in Japanese brown cattle is an autosomal recessive disorder characterized by short limbs. Previously, we mapped the locus responsible for the disease on the distal end of bovine chromosome 6. Here, we narrowed the critical region to approximately 2 cM by using linkage analysis, constructed a BAC and YAC contig covering this region, and identified a gene, LIMBIN (LBN), that possessed disease-specific mutations in the affected calves. One mutation was a single nucleotide ...[more]