Ontology highlight
ABSTRACT:
SUBMITTER: Yechoor VK
PROVIDER: S-EPMC124982 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Yechoor Vijay K VK Patti Mary-Elizabeth ME Saccone Robert R Kahn C Ronald CR
Proceedings of the National Academy of Sciences of the United States of America 20020729 16
Metabolic abnormalities underlying diabetes are primarily the result of the lack of adequate insulin action and the associated changes in protein phosphorylation and gene expression. To define the full set of alterations in gene expression in skeletal muscle caused by diabetes and the loss of insulin action, we have used Affymetrix oligonucleotide microarrays and streptozotocin-diabetic mice. Of the genes studied, 235 were identified as changed in diabetes, with 129 genes up-regulated and 106 do ...[more]