Ontology highlight
ABSTRACT:
SUBMITTER: Park KC
PROVIDER: S-EPMC124996 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Park Kyung Chan KC Kim Jung Hwa JH Choi Eun-Jung EJ Min Sang Won SW Rhee Sangmyung S Baek Sung Hee SH Chung Sung Soo SS Bang Oksun O Park Dongeun D Chiba Tomoki T Tanaka Keiji K Chung Chin Ha CH
Proceedings of the National Academy of Sciences of the United States of America 20020709 15
Protein modification by ubiquitin is a dynamic and reversible process that is involved in the regulation of a variety of cellular processes. Here, we show that myogenic differentiation of embryonic muscle cells is antagonistically regulated by two deubiquitinating enzymes, UBP45 and UBP69, that are generated by alternative splicing. Both enzymes cleaved off ubiquitin from polyubiquitinated protein conjugates in vivo as well as from linear ubiquitin-protein fusions in vitro. In cultured myoblasts ...[more]