Mechanisms for regulating deubiquitinating enzymes.
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ABSTRACT:
SUBMITTER: Wolberger C
PROVIDER: S-EPMC3970886 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Mechanisms for regulating deubiquitinating enzymes.
Protein science : a publication of the Protein Society 20140212 4
Ubiquitination is a reversible post-translational modification that plays a dynamic role in regulating most eukaryotic processes. Deubiquitinating enzymes (DUBs), which hydrolyze the isopeptide or peptide linkages joining ubiquitin to substrate lysines or N-termini, therefore play a key role in ubiquitin signaling. Cells employ multiple mechanisms to regulate DUB activity and thus ensure the appropriate biological response. Recent structural studies have shed light on several different mechanism ...[more]
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