Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.

ABSTRACT: In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.

SUBMITTER: Casey J 

PROVIDER: S-EPMC1251514 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature