Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.

ABSTRACT: We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.

SUBMITTER: Wieland SF 

PROVIDER: S-EPMC3993806 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature