Ontology highlight
ABSTRACT:
SUBMITTER: Roggo L
PROVIDER: S-EPMC125367 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Roggo Lorenz L Bernard Vincent V Kovacs Attila L AL Rose Ann M AM Savoy Fabienne F Zetka Monique M Wymann Matthias P MP Müller Fritz F
The EMBO journal 20020401 7
Here we present a detailed genetic analysis of let-512/vps34 that encodes the Caenorhabditis elegans homologue of the yeast phosphatidylinositol 3-kinase Vps34p. LET-512/VPS34 has essential functions and is ubiquitously expressed in all tissues and developmental stages. It accumulates at a perinuclear region, and mutations in let-512/vps34 result in an expansion of the outer nuclear membrane as well as in a mislocalization and subsequent complete lack of expression of LRP-1, a C.elegans LDL rece ...[more]