Ontology highlight
ABSTRACT:
SUBMITTER: Cohen M
PROVIDER: S-EPMC207014 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Cohen Merav M Feinstein Naomi N Wilson Katherine L KL Gruenbaum Yosef Y
Molecular biology of the cell 20030711 10
Gp210 is an evolutionarily conserved membrane protein of the nuclear pore complex (NPC). We studied the phenotypes produced by RNAi-induced downregulation of gp210 in both human (HeLa) cells and Caenorhabditis elegans embryos. HeLa cell viability requires Gp210 activity. The dying cells accumulated clustered NPCs and aberrant membrane structures at the nuclear envelope, suggesting that gp210 is required directly or indirectly for nuclear pore formation and dilation as well as the anchoring or st ...[more]