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A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.


ABSTRACT: In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo studies to demonstrate a role for this pathway in the stress response. We identified a Drosophila MAPK kinase kinase (MAPKKK), D-MEKK1, which can activate p38 MAPK. D-MEKK1 is structurally similar to the mammalian MEKK4/MTK1 MAPKKK. D-MEKK1 kinase activity was activated in animals under conditions of high osmolarity. Drosophila mutants lacking D-MEKK1 were hypersensitive to environmental stresses, including elevated temperature and increased osmolarity. In these D-MEKK1 mutants, activation of Drosophila p38 MAPK in response to stress was poor compared with activation in wild-type animals. These results suggest that D-MEKK1 regulation of the p38 MAPK pathway is critical for the response to environmental stresses in Drosophila.

SUBMITTER: Inoue H 

PROVIDER: S-EPMC125648 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature

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A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.

Inoue H H   Tateno M M   Fujimura-Kamada K K   Takaesu G G   Adachi-Yamada T T   Ninomiya-Tsuji J J   Irie K K   Nishida Y Y   Matsumoto K K  

The EMBO journal 20011001 19


In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo studies to demonstrate a role for this pathway in the stress response. We identified a Drosophila MAPK kinase kinase (MAPKKK), D-MEKK1, which can activate p38 MAPK. D-MEKK1 is structurally similar to the mammalian MEKK4/MTK1 MAPKKK. D-MEKK1 kinase activity was activated in animals under conditions of  ...[more]

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