Ontology highlight
ABSTRACT:
SUBMITTER: Coulthard LR
PROVIDER: S-EPMC3016890 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Coulthard Lydia R LR White Danielle E DE Jones Dominic L DL McDermott Michael F MF Burchill Susan A SA
Trends in molecular medicine 20090806 8
The p38(MAPK) protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis. In this review, we examine the regulatory and effector components of this pathway, focusing on their emerging roles in biological processes involved in different pathologies. We summarize how this pathway has been exploited for the development of therapeutics and discuss the potential ...[more]