Ontology highlight
ABSTRACT:
SUBMITTER: Taylor AB
PROVIDER: S-EPMC1257390 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Taylor Alexander B AB Stoj Christopher S CS Ziegler Lynn L Kosman Daniel J DJ Hart P John PJ
Proceedings of the National Academy of Sciences of the United States of America 20051017 43
Fet3p is a multicopper-containing glycoprotein localized to the yeast plasma membrane that catalyzes the oxidation of Fe(II) to Fe(III). This ferrous iron oxidation is coupled to the reduction of O(2) to H(2)O and is termed the ferroxidase reaction. Fet3p-produced Fe(III) is transferred to the permease Ftr1p for import into the cytosol. The posttranslational insertion of four copper ions into Fet3p is essential for its activity, thus linking copper and iron homeostasis. The mammalian ferroxidase ...[more]