Ontology highlight
ABSTRACT:
SUBMITTER: Michel F
PROVIDER: S-EPMC125740 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Michel F F Soler-Lopez M M Petosa C C Cramer P P Siebenlist U U Müller C W CW
The EMBO journal 20011101 22
IkappaB proteins associate with the transcription factor NF-kappaB via their ankyrin repeat domain. Bcl-3 is an unusual IkappaB protein because it is primarily nucleoplasmic and can lead to enhanced NF-kappaB-dependent transcription, unlike the prototypical IkappaB protein IkappaBalpha, which inhibits NF-kappaB activity by retaining it in the cytoplasm. Here we report the 1.9 A crystal structure of the ankyrin repeat domain of human Bcl-3 and compare it with that of IkappaBalpha bound to NF-kapp ...[more]