Ontology highlight
ABSTRACT:
SUBMITTER: McCleverty CJ
PROVIDER: S-EPMC2242602 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
McCleverty Clare J CJ Koesema Eric E Patapoutian Ardem A Lesley Scott A SA Kreusch Andreas A
Protein science : a publication of the Protein Society 20060801 9
TRPV channels are important polymodal integrators of noxious stimuli mediating thermosensation and nociception. An ankyrin repeat domain (ARD), which is a common protein-protein recognition domain, is conserved in the N-terminal intracellular domain of all TRPV channels and predicted to contain three to four ankyrin repeats. Here we report the first structure from the TRPV channel subfamily, a 1.7 A resolution crystal structure of the human TRPV2 ARD. Our crystal structure reveals a six ankyrin ...[more]