Searching for differentially expressed gene combinations.

ABSTRACT: We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.

SUBMITTER: Dettling M 

PROVIDER: S-EPMC1257471 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature