Ontology highlight
ABSTRACT:
SUBMITTER: Palangat M
PROVIDER: S-EPMC1257689 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Palangat Murali M Renner Dan B DB Price David H DH Landick Robert R
Proceedings of the National Academy of Sciences of the United States of America 20051007 42
Formation of productive transcription complexes after promoter escape by RNA polymerase II is a major event in eukaryotic gene regulation. Both negative and positive factors control this step. The principal negative elongation factor (NELF) contains four polypeptides and requires for activity the two-polypeptide 5,6-dichloro-1-beta-D-ribobenzimidazole-sensitivity inducing factor (DSIF). DSIF/NELF inhibits early transcript elongation until it is counteracted by the positive elongation factor P-TE ...[more]