Ontology highlight
ABSTRACT:
SUBMITTER: Fouqueau T
PROVIDER: S-EPMC5715097 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Fouqueau Thomas T Blombach Fabian F Hartman Ross R Cheung Alan C M ACM Young Mark J MJ Werner Finn F
Nature communications 20171204 1
TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation complex and inhibits transcription initiation and elongation. All inhibitory activities are dependent on three lysine residues at the tip of the C-terminal zinc ribbon of TFS4; the inh ...[more]