Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama K
PROVIDER: S-EPMC125810 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Yokoyama Kazumasa K Su Ih I-hsin IH Tezuka Tohru T Yasuda Tomoharu T Mikoshiba Katsuhiko K Tarakhovsky Alexander A Yamamoto Tadashi T
The EMBO journal 20020101 1-2
B-cell activation mediated through the antigen receptor is dependent on activation of protein tyrosine kinases (PTKs) such as Lyn and Syk and subsequent phosphorylation of various signaling proteins. Here we report on the identification and characterization of the B-cell scaffold protein with ankyrin repeats (BANK), a novel substrate of tyrosine kinases. BANK is expressed in B cells and is tyrosine phosphorylated upon B-cell antigen receptor (BCR) stimulation, which is mediated predominantly by ...[more]