Ontology highlight
ABSTRACT:
SUBMITTER: Dulubova I
PROVIDER: S-EPMC126126 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Dulubova Irina I Yamaguchi Tomohiro T Gao Yan Y Min Sang-Won SW Huryeva Iryna I Südhof Thomas C TC Rizo Josep J
The EMBO journal 20020701 14
Soluble N-ethylmaleimide sensitive factor-attachment protein receptors (SNAREs) and Sec1p/Munc18-homologs (SM proteins) play key roles in intracellular membrane fusion. The SNAREs form tight four-helix bundles (core complexes) that bring the membranes together, but it is unclear how this activity is coupled to SM protein function. Studies of the yeast trans-Golgi network (TGN)/endosomal SNARE complex, which includes the syntaxin-like SNARE Tlg2p, have suggested that its assembly requires activat ...[more]