Ontology highlight
ABSTRACT:
SUBMITTER: Mishra SK
PROVIDER: S-EPMC1262658 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Mishra Sandip K SK Talukder Amjad H AH Gururaj Anupama E AE Yang Zhibo Z Singh Rajesh R RR Mahoney My G MG Francí Clara C Vadlamudi Ratna K RK Kumar Rakesh R
The Journal of biological chemistry 20040528 31
Although recent studies have shown a role of estrogen receptor-alpha (ER) in the regulation of epithelial-to-mesenchymal transition via MTA3, the role of upstream determinants of ER regulation of MTA3 and the underlying molecular mechanism remains unknown. Here we show that MTA3 gene regulation by ER is influenced by dynamic changes in levels of nuclear coregulators. MTA3 promoter has a functional ER element half-site with which MTA1 and HDACs interact under basal conditions. Upon estrogen stimu ...[more]