Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian K
PROVIDER: S-EPMC2567917 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Subramanian Krithika K Jia Da D Kapoor-Vazirani Priya P Powell Doris R DR Collins Robert E RE Sharma Dipali D Peng Junmin J Cheng Xiaodong X Vertino Paula M PM
Molecular cell 20080501 3
Estrogen receptor alpha (ER) is a ligand-dependent transcription factor. Upon binding estrogen, ER recruits coactivator complexes with histone acetyltransferase or methyltransferase activities to activate downstream target genes. In addition to histones, coactivators can modify ER itself and other proteins in the transactivation complex. Here, we show that ER is directly methylated at lysine 302 (K302) by the SET7 methyltransferase. SET7-mediated methylation stabilizes ER and is necessary for th ...[more]