Hybrid dynamic/static method for large-scale simulation of metabolism.

ABSTRACT:

Background

Many computer studies have employed either dynamic simulation or metabolic flux analysis (MFA) to predict the behaviour of biochemical pathways. Dynamic simulation determines the time evolution of pathway properties in response to environmental changes, whereas MFA provides only a snapshot of pathway properties within a particular set of environmental conditions. However, owing to the large amount of kinetic data required for dynamic simulation, MFA, which requires less information, has been used to manipulate large-scale pathways to determine metabolic outcomes.

Results

Here we describe a simulation method based on cooperation between kinetics-based dynamic models and MFA-based static models. This hybrid method enables quasi-dynamic simulations of large-scale met

SUBMITTER: Yugi K 

PROVIDER: S-EPMC1262783 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature