Ontology highlight
ABSTRACT:
SUBMITTER: Nawroth R
PROVIDER: S-EPMC126293 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Nawroth Roman R Poell Gregor G Ranft Alexander A Kloep Stephan S Samulowitz Ulrike U Fachinger Gregor G Golding Matthew M Shima David T DT Deutsch Urban U Vestweber Dietmar D
The EMBO journal 20020901 18
VE-cadherin is the essential adhesion molecule in endothelial adherens junctions, and the regulation of protein tyrosine phosphorylation is thought to be important for the control of adherens junction integrity. We show here that VE-PTP (vascular endothelial protein tyrosine phosphatase), an endothelial receptor-type phosphatase, co-precipitates with VE-cadherin, but not with beta-catenin, from cell lysates of transfected COS-7 cells and of endothelial cells. Co-precipitation of VE-cadherin and ...[more]