Ontology highlight
ABSTRACT:
SUBMITTER: Juettner VV
PROVIDER: S-EPMC6504901 | biostudies-other | 2019 May
REPOSITORIES: biostudies-other
Juettner Vanessa V VV Kruse Kevin K Dan Arkaprava A Vu Vinh H VH Khan Yousaf Y Le Jonathan J Leckband Deborah D Komarova Yulia Y Malik Asrar B AB
The Journal of cell biology 20190404 5
Vascular endothelial (VE) protein tyrosine phosphatase (PTP) is an endothelial-specific phosphatase that stabilizes VE-cadherin junctions. Although studies have focused on the role of VE-PTP in dephosphorylating VE-cadherin in the activated endothelium, little is known of VE-PTP's role in the quiescent endothelial monolayer. Here, we used the photoconvertible fluorescent protein VE-cadherin-Dendra2 to monitor VE-cadherin dynamics at adherens junctions (AJs) in confluent endothelial monolayers. W ...[more]