Ontology highlight
ABSTRACT:
SUBMITTER: Tournu H
PROVIDER: S-EPMC1265895 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Tournu Hélène H Tripathi Gyanendra G Bertram Gwyneth G Macaskill Susan S Mavor Abigail A Walker Louise L Odds Frank C FC Gow Neil A R NA Brown Alistair J P AJ
Eukaryotic cell 20051001 10
The pathogen Candida albicans responds to amino acid starvation by activating pseudohyphal development and the expression of amino acid biosynthetic genes (GCN response). In Saccharomyces cerevisiae, the GCN response is dependent on Gcn2, which regulates the translation of the transcription factor Gcn4. Therefore, we examined the role of Gcn2 in C. albicans by using molecular, cellular, and genomic approaches. We show that C. albicans GCN2 encodes an eIF2alpha kinase, like its S. cerevisiae homo ...[more]