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TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.

ABSTRACT: TEM-71, a novel extended-spectrum beta-lactamase from a Klebsiella pneumoniae clinical isolate, had an isoelectric point of 6.0 and a substrate profile showing preferential hydrolysis of cefotaxime over ceftazidime. It differed from TEM-1 by two substitutions, Gly238Ser and Glu240Lys, and was under the control of the strong P4 promoter.

SUBMITTER: Rasheed JK

PROVIDER: S-EPMC127224 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature

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TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.

Rasheed J Kamile JK Anderson Gregory J GJ Queenan Anne Marie AM Biddle James W JW Oliver Antonio A Jacoby George A GA Bush Karen K Tenover Fred C FC

Antimicrobial agents and chemotherapy 20020601 6

TEM-71, a novel extended-spectrum beta-lactamase from a Klebsiella pneumoniae clinical isolate, had an isoelectric point of 6.0 and a substrate profile showing preferential hydrolysis of cefotaxime over ceftazidime. It differed from TEM-1 by two substitutions, Gly238Ser and Glu240Lys, and was under the control of the strong P4 promoter. ...[more]

PMID: 12019125

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