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Biochemical characterization of the TEM-107 extended-spectrum ?-lactamase in a Klebsiella pneumoniae isolate from South Korea.

ABSTRACT: The TEM-107 extended-spectrum ?-lactamase detected in a Klebsiella pneumoniae clinical isolate had a Gly238Ser substitution compared to the TEM-43 ?-lactamase. The MIC of ceftazidime was higher (64 ?g/ml) than that of cefotaxime (2 ?g/ml) for the isolate. Clavulanic acid reduced the MIC of ceftazidime 64-fold.

SUBMITTER: Lee K

PROVIDER: S-EPMC3232759 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.

Lee Kyungwon K Yum Jong Hwa JH Yong Dongeun D Jeong Seok Hoon SH Rossolini Gian Maria GM Docquier Jean-Denis JD Chong Yunsop Y

Antimicrobial agents and chemotherapy 20110912 12

The TEM-107 extended-spectrum β-lactamase detected in a Klebsiella pneumoniae clinical isolate had a Gly238Ser substitution compared to the TEM-43 β-lactamase. The MIC of ceftazidime was higher (64 μg/ml) than that of cefotaxime (2 μg/ml) for the isolate. Clavulanic acid reduced the MIC of ceftazidime 64-fold. ...[more]

PMID: 21911565

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