Ontology highlight
ABSTRACT:
SUBMITTER: Braibant M
PROVIDER: S-EPMC127400 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Braibant Martine M Guilloteau Laurence L Zygmunt Michel S MS
Antimicrobial agents and chemotherapy 20020901 9
Two putative proteins (NorMI and NorMII) similar to the multidrug efflux protein NorM of Vibrio parahaemolyticus are encoded by the Brucella melitensis 16 M genome. We show that a drug-hypersusceptible Escherichia coli strain overexpressing NorMI displays increased resistance to norfloxacin, ciprofloxacin, gentamicin, tetraphenylphosphonium ion, acriflavine, and berberine. This elevated resistance was proven to be mediated by an energy-dependent efflux mechanism. NorMI belongs to the multidrug a ...[more]