Ontology highlight
ABSTRACT:
SUBMITTER: Honma K
PROVIDER: S-EPMC1276050 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Honma Kiri K Udono Heiichiro H Kohno Tomoko T Yamamoto Kazuo K Ogawa Asako A Takemori Toshitada T Kumatori Atsushi A Suzuki Shoichi S Matsuyama Toshifumi T Yui Katsuyuki K
Proceedings of the National Academy of Sciences of the United States of America 20051021 44
A member of the IFN regulatory factor (IRF) family of transcription factors, IRF-4 is expressed in lymphocytes and macrophage/dendritic cells. Studies using IRF-4-deficient mice have revealed the critical roles of IRF-4 in lymphocyte responses. However, the role of IRF-4 in innate immune responses is not clearly understood. Here, we demonstrate that IRF-4 negatively regulates the production of proinflammatory cytokines by macrophages in response to Toll-like receptor (TLR) stimulation. Mice lack ...[more]