Entamoeba histolytica lectins contain unique 6-Cys or 8-Cys chitin-binding domains.
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ABSTRACT:
SUBMITTER: Van Dellen K
PROVIDER: S-EPMC127964 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
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Entamoeba histolytica lectins contain unique 6-Cys or 8-Cys chitin-binding domains.
Van Dellen Katrina K Ghosh Sudip K SK Robbins Phillips W PW Loftus Brendan B Samuelson John J
Infection and immunity 20020601 6
The Jacob lectin, the most abundant glycoprotein in the cyst wall of Entamoeba invadens, contains five unique 6-Cys chitin-binding domains (CBDs). We identified Entamoeba histolytica and Entamoeba dispar genes encoding Jacob homologues, each of which contains two predicted 6-Cys CBDs. A unique 8-Cys CBD was found at the N termini of the E. histolytica chitinase and three other predicted lectins, called Jessie 1 to Jessie 3. The CBDs of four E. histolytica lectins (Jacob, chitinase, and Jessies 2 ...[more]
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