Ontology highlight
ABSTRACT:
SUBMITTER: Hearnes JM
PROVIDER: S-EPMC1280257 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Hearnes Jamie M JM Mays Deborah J DJ Schavolt Kristy L KL Tang Luojia L Jiang Xin X Pietenpol Jennifer A JA
Molecular and cellular biology 20051101 22
In various human diseases, altered gene expression patterns are often the result of deregulated gene-specific transcription factor activity. To further understand disease on a molecular basis, the comprehensive analysis of transcription factor signaling networks is required. We developed an experimental approach, combining chromatin immunoprecipitation (ChIP) with a yeast-based assay, to screen the genome for transcription factor binding sites that link to transcriptionally regulated target gene ...[more]