Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC128345 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Sun Shuhua S Scheffler N Karoline NK Gibson Bradford W BW Wang Jing J Munson Robert S RS
Infection and immunity 20021001 10
Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted ulcerative disease. In the present study, the Neisseria gonorrhoeae lgtA lipooligosaccharide glycosyltransferase gene was used to identify a homologue in the genome of H. ducreyi. The putative H. ducreyi glycosyltransferase gene (designated lgtA) was cloned and insertionally inactivated, and an isogenic mutant was constructed. Structural studies demonstrated that the lipooligosaccharide isolated from the mutant strai ...[more]