Ontology highlight
ABSTRACT:
SUBMITTER: Wang PY
PROVIDER: S-EPMC1283469 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Wang Pei-Yu PY Koishi Kyoko K McGeachie Andrew B AB Kimber Michael M Maclaughlin David T DT Donahoe Patricia K PK McLennan Ian S IS
Proceedings of the National Academy of Sciences of the United States of America 20051031 45
The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor. We find that motor neurons from adult mice synthesize MIS and express its receptors, suggesting that mature motor neurons use MIS in an autocrine fashion or as a way to communicat ...[more]