Ontology highlight
ABSTRACT:
SUBMITTER: Granneman S
PROVIDER: S-EPMC1291222 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Granneman Sander S Nandineni Madhusudan R MR Baserga Susan J SJ
Molecular and cellular biology 20051201 23
One of the proteins identified as being involved in ribosome biogenesis by high-throughput studies, a putative P-loop-type kinase termed Fap7 (YDL166c), was shown to be required for the conversion of 20S pre-rRNA to 18S rRNA. However, the mechanism underlying this function has remained unclear. Here we demonstrate that Fap7 is strictly required for cleavage of the 20S pre-rRNA at site D in the cytoplasm. Genetic depletion of Fap7 causes accumulation of only the 20S pre-rRNA, which could be detec ...[more]