Ontology highlight
ABSTRACT:
SUBMITTER: Harris PK
PROVIDER: S-EPMC1291349 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Harris Philippa K PK Yeoh Sharon S Dluzewski Anton R AR O'Donnell Rebecca A RA Withers-Martinez Chrislaine C Hackett Fiona F Bannister Lawrence H LH Mitchell Graham H GH Blackman Michael J MJ
PLoS pathogens 20051125 3
Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor complexes in order to gain entry into their host cell. Erythrocyte invasion by merozoites of the malaria parasite Plasmodium falciparum requires the shedding of ectodomain components of two essential surface proteins, called MSP1 and AMA1. Both are released by the same merozoite surface "sheddase," but th ...[more]