The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain.
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ABSTRACT:
SUBMITTER: Baker ML
PROVIDER: S-EPMC129414 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
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The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain.
Baker Matthew L ML Serysheva Irina I II Sencer Serap S Wu Yili Y Ludtke Steven J SJ Jiang Wen W Hamilton Susan L SL Chiu Wah W
Proceedings of the National Academy of Sciences of the United States of America 20020906 19
We used a combination of bioinformatics, electron cryomicroscopy, and biochemical techniques to identify an oxidoreductase-like domain in the skeletal muscle Ca2+ release channel protein (RyR1). The initial prediction was derived from sequence-based fold recognition for the N-terminal region (41-420) of RyR1. The putative domain was computationally localized to the clamp domain in the cytoplasmic region of a 22A structure of RyR1. This localization was subsequently confirmed by difference imagin ...[more]
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